Conditioned Media from Mesenchymal Stem Cells Enhanced Bone Regeneration in Rat Calvarial Bone Defects
نویسندگان
چکیده
منابع مشابه
Erratum: Bone regeneration of mouse critical-sized calvarial defects with human mesenchymal stem cells in scaffold
Combination of tissue engineering and cell therapy represents a promising approach for bone regeneration. Human mesenchymal stem cells (hMSCs) have properties that include low immunogenicity, high proliferation rate, and multi-differentiation potential; therefore, they are an attractive seeding source for tissue engineering therapy. Here we found that hMSCs with a scaffold did not affect cell v...
متن کاملBone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids
Mesenchymal stem cell (MSC) condensation contributes to membrane ossification by enhancing their osteodifferentiation. We investigated bone regeneration in rats using the human bone marrow-derived MSC-spheroids prepared by rotation culture, without synthetic or exogenous biomaterials. Bilateral calvarial defects (8 mm) were created in nude male rats; the left-sided defects were implanted with M...
متن کاملHarvesting of bone marrow mesenchymal stem cells from live rats and the in vitro differentiation of bone marrow mesenchymal stem cells into neuron-like cells
In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...
متن کاملMesenchymal stem cells and bone regeneration.
OBJECTIVE To review the role of mesenchymal stem cells (MSC) in bone formation and regeneration, and outline the development of strategies that use MSC in bone healing and regeneration. STUDY DESIGN Literature review. METHODS Medline review, synopses of authors' published research. RESULTS The MSC is the basic cellular unit of embryologic bone formation. Secondary bone healing mimics bone...
متن کاملreconstructing calvarial bone lesions using phbv scaffolds and cord blood mesenchymal stem cells in rat
background: for tissue engineering of bone, anatomical and operational reconstructions of damaged tissue seem to be vital. this is done via reconstruction of bone and appropriate biological joint with bone tissues of damaged areas. in this study the condition of biodegradable bed nano fiber phbv and ussc cells were used to accelerate bone repair of damaged area. methods: hollow nanofabrication ...
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ژورنال
عنوان ژورنال: Tissue Engineering Part A
سال: 2012
ISSN: 1937-3341,1937-335X
DOI: 10.1089/ten.tea.2011.0325